Organogenesis Company, Canton Massachusetts, developed artificial made skin, from the cells of infant foreskin, called Apligraf. A Boston hospital provides the company with sample infant foreskin. The samples are broken down into their cellular components, were those cells are seeded into a petri dish, filled with bovine collagen. The cells grow in cell banks. A single infant foreskin sample produces 200,000 skin samples of Apligraf. Approximately, three weeks later, the human equivalent skin is teased out of the petri dish.In Podiatry Today they reviewed the use of these tissues to treat diabetic foot ulcers that do not respond to standard woud care.
According to Organogenesis, in Canada approximately 150,000 people, with open wounds, such as venous ulcers and burns, can benefit from Apligraf. Major advantage of Apiligraf, no rejection and no imuno-suppression required.
Badiavas, et al., examined the grafthost interaction of Apligraf treated wounds via biopsy two weeks after application. Histologic examination found degeneration of the Apligraf collagen and dermal cells, and the presence of excess mucin indicated a mutual stimulatory interaction between the host wound bed and allograft.This finding indicates that the Apligraf fibroblasts may serve as a living tissue that stimulates host and graft cells to produce excess ground substance, which elicits a wound healing response.